Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms

The transcription factor “nuclear factor erythroid 2” (NFE2) is overexpressed in the majority of patients with myeloproliferative neoplasms (MPNs). In murine models, elevated NFE2 levels cause an MPN phenotype with spontaneous leukemic transformation. However, both the molecular mechanisms leading t...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Peeken, Jan C., Jutzi, Jonas S., Wehrle, Julius, Koellerer, Christoph, Staehle, Hans F., Becker, Heiko, Schoenwandt, Elias, Seeger, Thalia S., Schanne, Daniel H., Gothwal, Monika, Ott, Christopher J., Gründer, Albert, Pahl, Heike L.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2018
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934799/
https://ncbi.nlm.nih.gov/pubmed/29519804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-10-810622
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