Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms

The transcription factor “nuclear factor erythroid 2” (NFE2) is overexpressed in the majority of patients with myeloproliferative neoplasms (MPNs). In murine models, elevated NFE2 levels cause an MPN phenotype with spontaneous leukemic transformation. However, both the molecular mechanisms leading t...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Peeken, Jan C., Jutzi, Jonas S., Wehrle, Julius, Koellerer, Christoph, Staehle, Hans F., Becker, Heiko, Schoenwandt, Elias, Seeger, Thalia S., Schanne, Daniel H., Gothwal, Monika, Ott, Christopher J., Gründer, Albert, Pahl, Heike L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934799/
https://ncbi.nlm.nih.gov/pubmed/29519804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-10-810622
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