Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

Advances in the hematopoietic stem cell (HSCs) field have been aided by methods to genetically engineer primary progenitor cells as well as animal models. Complete gene ablation in HSCs required the generation of knockout mice from which HSCs could be isolated, and gene ablation in primary human HSC...

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Detaylı Bibliyografya
Yayımlandı:J Vis Exp
Asıl Yazarlar: Brunetti, Lorenzo, Gundry, Michael C., Kitano, Ayumi, Nakada, Daisuke, Goodell, Margaret A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MyJove Corporation 2018
Konular:
Genetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5933422/
https://ncbi.nlm.nih.gov/pubmed/29708546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/57278
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