Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells

Mutations accumulating in hematopoietic stem and progenitor cells (HSPCs) during development can cause severe hematological disorders. Modeling these mutations in mice is essential for understanding their functional consequences. Here, we describe an efficient CRISPR/Cas9-based system to knock in an...

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Publicado no:Cell Rep
Main Authors: Tran, Ngoc Tung, Sommermann, Thomas, Graf, Robin, Trombke, Janine, Pempe, Jenniffer, Petsch, Kerstin, Kühn, Ralf, Rajewsky, Klaus, Chu, Van Trung
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899516/
https://ncbi.nlm.nih.gov/pubmed/31553918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.065
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