Start codon disruption with CRISPR/Cas9 prevents murine Fuchs’ endothelial corneal dystrophy

A missense mutation of collagen type VIII alpha 2 chain (COL8A2) gene leads to early-onset Fuchs’ endothelial corneal dystrophy (FECD), which progressively impairs vision through the loss of corneal endothelial cells. We demonstrate that CRISPR/Cas9-based postnatal gene editing achieves structural a...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Uehara, Hironori, Zhang, Xiaohui, Pereira, Felipe, Narendran, Siddharth, Choi, Susie, Bhuvanagiri, Sai, Liu, Jinlu, Ravi Kumar, Sangeetha, Bohner, Austin, Carroll, Lara, Archer, Bonnie, Zhang, Yue, Liu, Wei, Gao, Guangping, Ambati, Jayakrishna, Jun, Albert S, Ambati, Balamurali K
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8216720/
https://ncbi.nlm.nih.gov/pubmed/34100716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55637
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