Antisecretory Factor-mediated Inhibition of Cell Volume Dynamics Produces Anti-tumor Activity in Glioblastoma

Interstitial fluid pressure (IFP) presents a barrier to drug uptake in solid tumors, including the aggressive primary brain tumor glioblastoma multiforme (GBM). It remains unclear how fluid dynamics impacts tumor progression and can be targeted therapeutically. To address this issue, a novel telemet...

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Veröffentlicht in:Mol Cancer Res
Hauptverfasser: Ilkhanizadeh, Shirin, Sabelström, Hanna, Miroshnikova, Yekaterina A., Frantz, Aaron, Zhu, Wen, Idilli, Aurora, Lakins, Jon N., Schmidt, Christin, Quigley, David A., Fenster, Trenten, Yuan, Edith, Trzeciak, Jacqueline R., Saxena, Supna, Lindberg, Olle R., Mouw, Janna K., Burdick, Jason A., Magnitsky, Sergey, Berger, Mitchel S., Phillips, Joanna J., Arosio, Daniele, Sun, Dandan, Weaver, Valerie M., Weiss, William A., Persson, Anders I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932284/
https://ncbi.nlm.nih.gov/pubmed/29431617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0413
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