In vitro and in vivo activity of IMGN853, an Antibody-Drug Conjugate targeting Folate Receptor Alpha linked to DM4, in biologically aggressive endometrial cancers

Grade 3 endometrioid and uterine serous carcinomas (USC) account for the vast majority of endometrial cancer deaths. The purpose of this study was to determine folic acid receptor alpha (FRα) expression in these biologically aggressive (Type II) endometrial cancers, and evaluate FRα as a targetable...

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Publicado en:Mol Cancer Ther
Main Authors: Altwerger, Gary, Bonazzoli, Elena, Bellone, Stefania, Egawa-Takata, Tomomi, Menderes, Gulden, Pettinella, Francesca, Bianchi, Anna, Riccio, Francesco, Feinberg, Jacqueline, Zammataro, Luca, Han, Chanhee, Yadav, Ghanshyam, Dugan, Katherine, Morneault, Ashley, Ponte, Jose F., Buza, Natalia, Hui, Pei, Wong, Serena, Litkouhi, Babak, Ratner, Elena, Silasi, Dan-Arin, Huang, Gloria S., Azodi, Masoud, Schwartz, Peter E., Santin, Alessandro D.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932245/
https://ncbi.nlm.nih.gov/pubmed/29440294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0930
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