Inhibition of BET bromodomain proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a biologically aggressive variant of Endometrial Cancer

PURPOSE: Uterine-serous-carcinoma (USC) is a rare and aggressive variant of endometrial cancer. Whole-exome-sequencing (WES) studies have recently reported c-Myc gene amplification in large number of USC suggesting c-Myc as a potential therapeutic target. We investigated the activity of novel BET br...

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Pubblicato in:Clin Cancer Res
Autori principali: Bonazzoli, Elena, Predolini, Federica, Cocco, Emiliano, Bellone, Stefania, Altwerger, Gary, Menderes, Gulden, Zammataro, Luca, Bianchi, Anna, Pettinella, Francesca, Riccio, Francesco, Han, Chanhee, Yadav, Ghanshyam, Lopez, Salvatore, Manzano, Aranzazu, Manara, Paola, Buza, Natalia, Hui, Pei, Wong, Serena, Litkouhi, Babak, Ratner, Elena, Silasi, Dan-Arin, Huang, Gloria S., Azodi, Masoud, Schwartz, Peter E., Schlessinger, Joseph, Santin, Alessandro D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168417/
https://ncbi.nlm.nih.gov/pubmed/29941483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0864
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