Derangements in HUWE1/c-MYC pathway confer sensitivity to the BET bromodomain inhibitor GS-626510 in uterine cervical carcinoma

OBJECTIVE: Whole-exome-sequencing (WES) studies reported c-MYC gene-amplification and HUWE1 gene deletion/mutations in a significant number of cervical-cancer-patients (CC) suggesting HUWE1/c-MYC pathway as potential therapeutic target. We investigated HUWE1/c-MYC expression in fresh-frozen-CC and t...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Gynecol Oncol
Glavni autori: Bonazzoli, Elena, Bellone, Stefania, Zammataro, Luca, Gnutti, Barbara, Guglielmi, Adele, Pelligra, Silvia, Nagarkatti, Nupur, Manara, Paola, Tymon-Rosario, Joan, Zeybek, Burak, Altwerger, Gary, Menderes, Gulden, Han, Chanhee, Ratner, Elena, Silasi, Dan-Arin, Huang, Gloria S., Andikyan, Vaagn, Azodi, Masoud, Schwartz, Peter E., Santin, Alessandro D.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8253557/
https://ncbi.nlm.nih.gov/pubmed/32600791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2020.06.484
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items