Derangements in HUWE1/c-MYC pathway confer sensitivity to the BET bromodomain inhibitor GS-626510 in uterine cervical carcinoma

OBJECTIVE: Whole-exome-sequencing (WES) studies reported c-MYC gene-amplification and HUWE1 gene deletion/mutations in a significant number of cervical-cancer-patients (CC) suggesting HUWE1/c-MYC pathway as potential therapeutic target. We investigated HUWE1/c-MYC expression in fresh-frozen-CC and t...

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Publicado no:Gynecol Oncol
Main Authors: Bonazzoli, Elena, Bellone, Stefania, Zammataro, Luca, Gnutti, Barbara, Guglielmi, Adele, Pelligra, Silvia, Nagarkatti, Nupur, Manara, Paola, Tymon-Rosario, Joan, Zeybek, Burak, Altwerger, Gary, Menderes, Gulden, Han, Chanhee, Ratner, Elena, Silasi, Dan-Arin, Huang, Gloria S., Andikyan, Vaagn, Azodi, Masoud, Schwartz, Peter E., Santin, Alessandro D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8253557/
https://ncbi.nlm.nih.gov/pubmed/32600791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2020.06.484
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