In vitro and in vivo activity of IMGN853, an Antibody-Drug Conjugate targeting Folate Receptor Alpha linked to DM4, in biologically aggressive endometrial cancers

Grade 3 endometrioid and uterine serous carcinomas (USC) account for the vast majority of endometrial cancer deaths. The purpose of this study was to determine folic acid receptor alpha (FRα) expression in these biologically aggressive (Type II) endometrial cancers, and evaluate FRα as a targetable...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mol Cancer Ther
Main Authors: Altwerger, Gary, Bonazzoli, Elena, Bellone, Stefania, Egawa-Takata, Tomomi, Menderes, Gulden, Pettinella, Francesca, Bianchi, Anna, Riccio, Francesco, Feinberg, Jacqueline, Zammataro, Luca, Han, Chanhee, Yadav, Ghanshyam, Dugan, Katherine, Morneault, Ashley, Ponte, Jose F., Buza, Natalia, Hui, Pei, Wong, Serena, Litkouhi, Babak, Ratner, Elena, Silasi, Dan-Arin, Huang, Gloria S., Azodi, Masoud, Schwartz, Peter E., Santin, Alessandro D.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2018
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932245/
https://ncbi.nlm.nih.gov/pubmed/29440294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0930
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