Superior in vitro and in vivo activity of trastuzumab-emtansine (T-DM1) in comparison to trastuzumab, pertuzumab and their combination in epithelial ovarian carcinoma with high HER2/neu expression

BACKGROUND: Epithelial ovarian cancer (EOC) remains the most lethal gynecologic malignancy. The objective of this study was to compare the anti-tumor activity of HER2/neu-targeting monoclonal antibodies, trastuzumab (T), pertuzumab (P), combination of trastuzumab and pertuzumab (T+P) and trastuzumab...

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Udgivet i:Gynecol Oncol
Main Authors: Menderes, Gulden, Bonazzoli, Elena, Bellone, Stefania, Altwerger, Gary, Black, Jonathan D., Dugan, Katherine, Pettinella, Francesca, Masserdotti, Alice, Riccio, Francesco, Bianchi, Anna, Zammataro, Luca, deHaydu, Christopher, Buza, Natalia, Hui, Pei, Wong, Serena, Huang, Gloria S., Litkouhi, Babak, Ratner, Elena, Silasi, Dan-Arin, Azodi, Masoud, Schwartz, Peter E., Santin, Alessandro D.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605415/
https://ncbi.nlm.nih.gov/pubmed/28705408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2017.07.009
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