A Human Genome-wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation

Activation of the unfolded protein response (UPR) signaling pathways is linked to multiple human diseases including cancer. The inositol-requiring kinase 1α (IRE1α)-X-box binding protein 1 (XBP1) pathway is the most evolutionarily conserved of the three major signaling branches of the UPR. Here, we...

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Vydáno v:Mol Cancer Res
Hlavní autoři: Yang, Zhifen, Zhang, Jing, Jiang, Dadi, Khatri, Purvesh, Solow-Cordero, David E., Toesca, Diego A.S., Koumenis, Constantinos, Denko, Nicholas C., Giaccia, Amato J., Le, Quynh-Thu, Koong, Albert C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932228/
https://ncbi.nlm.nih.gov/pubmed/29440447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0307
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