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Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus
Since the discovery of the T cell receptor (TcR), immunologists have assigned somatic hypermutation (SHM) as a mechanism employed solely by B cells to diversify their antigen receptors. Remarkably, we found SHM acting in the thymus on α chain locus of shark TcR. SHM in developing shark T cells likel...
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| Опубликовано в: : | eLife |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
eLife Sciences Publications, Ltd
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5931798/ https://ncbi.nlm.nih.gov/pubmed/29664399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28477 |
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