The multiple shark immunoglobulin heavy chain genes rearrange and hypermutate autonomously()

Sharks and skates are representatives of the earliest vertebrates with an immune system based on V(D)J rearrangement. They possess a unique Ig gene organization consisting of 15 to >50 individual IgM loci, each with one VH, two DH, one JH and one set of constant region exons. The present study at...

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Bibliografiske detaljer
Main Authors: Zhu, Catherine, Feng, Wendy, Weedon, Jeremy, Hua, Pauline, Stefanov, Dimitre, Ohta, Yuko, Flajnik, Martin F., Hsu, Ellen
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190574/
https://ncbi.nlm.nih.gov/pubmed/21804022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101671
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