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Lost structural and functional inter-relationships between Ig and TCR loci in mammals revealed in sharks

Immunoglobulins and T cell receptors (TCR) have obvious structural similarities as well as similar immunogenetic diversification and selection mechanisms. Nevertheless, the two receptor systems and the loci that encode them are distinct in humans and classical murine models, and the gene segments co...

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Bibliografiske detaljer
Udgivet i:Immunogenetics
Main Authors: Ott, Jeannine A., Ohta, Yuko, Flajnik, Martin F., Criscitiello, Michael F.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7909615/
https://ncbi.nlm.nih.gov/pubmed/33449123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00251-020-01183-5
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