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Lost structural and functional inter-relationships between Ig and TCR loci in mammals revealed in sharks

Immunoglobulins and T cell receptors (TCR) have obvious structural similarities as well as similar immunogenetic diversification and selection mechanisms. Nevertheless, the two receptor systems and the loci that encode them are distinct in humans and classical murine models, and the gene segments co...

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Détails bibliographiques
Publié dans:Immunogenetics
Auteurs principaux: Ott, Jeannine A., Ohta, Yuko, Flajnik, Martin F., Criscitiello, Michael F.
Format: Artigo
Langue:Inglês
Publié: 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7909615/
https://ncbi.nlm.nih.gov/pubmed/33449123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00251-020-01183-5
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