Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors

Recently, FGFR1 was found to be overexpressed in osteosarcoma and represents an important target for precision medicine. However, because targeted cancer therapy based on FGFR inhibitors has so far been less efficient than expected, a detailed understanding of the target is important. We have here a...

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Foilsithe in:Mol Cell Proteomics
Main Authors: Kostas, Michal, Haugsten, Ellen Margrethe, Zhen, Yan, Sørensen, Vigdis, Szybowska, Patrycja, Fiorito, Elisa, Lorenz, Susanne, Jones, Nina, de Souza, Gustavo Antonio, Wiedlocha, Antoni, Wesche, Jørgen
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2018
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930401/
https://ncbi.nlm.nih.gov/pubmed/29371290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA117.000538
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