Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors

Recently, FGFR1 was found to be overexpressed in osteosarcoma and represents an important target for precision medicine. However, because targeted cancer therapy based on FGFR inhibitors has so far been less efficient than expected, a detailed understanding of the target is important. We have here a...

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Bibliographic Details
Published in:Mol Cell Proteomics
Main Authors: Kostas, Michal, Haugsten, Ellen Margrethe, Zhen, Yan, Sørensen, Vigdis, Szybowska, Patrycja, Fiorito, Elisa, Lorenz, Susanne, Jones, Nina, de Souza, Gustavo Antonio, Wiedlocha, Antoni, Wesche, Jørgen
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2018
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930401/
https://ncbi.nlm.nih.gov/pubmed/29371290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA117.000538
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