Development and validation of an HPLC–MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study

PURPOSE: To develop and validate a bio-analytical HPLC–MS/MS method for the determination of conivaptan (CVA) an arginine-vasopressin receptor blocker in human plasma and in rat liver microsomes (RLMs). METHODS: Analytes were separated on a reversed phase C18 column (50 mm × 2.1 mm, 1.8 μm). The mob...

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Udgivet i:Chem Cent J
Main Authors: Alrabiah, Haitham, Kadi, Adnan A., Attwa, Mohamed W., Mostafa, Gamal A. E.
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930294/
https://ncbi.nlm.nih.gov/pubmed/29717376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-018-0414-5
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