A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma

BACKGROUND: Dovitinib (TKI 258) is a small-molecule multi-kinase inhibitor for the treatment of different types of cancer. There is currently no validated method for its quantitative determination; therefore, we aimed to develop a reliable method to assay dovitinib. METHOD AND RESULTS: An electrospr...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: AlRabiah, Haitham, Kadi, Adnan A, Aljohar, Haya I, Attwa, Mohamed W, Al-Shakliah, Nasser S, Attia, Sabry M, Mostafa, Gamal AE
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995292/
https://ncbi.nlm.nih.gov/pubmed/32095071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S223573
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