A Validated LC–MS/MS Assay for the Simultaneous Quantification of the FDA-Approved Anticancer Mixture (Encorafenib and Binimetinib): Metabolic Stability Estimation

The concurrent use of oral encorafenib (Braftovi, ENF) and binimetinib (Mektovi, BNB) is a combination anticancer therapy approved by the United States Food and Drug Administration (USFDA) for patients with BRAFV600E/V600K mutations suffering from metastatic or unresectable melanoma. Metabolism is c...

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Enregistré dans:
Détails bibliographiques
Publié dans:Molecules
Auteurs principaux: Attwa, Mohamed W., Darwish, Hany W., Al-Shakliah, Nasser S., Kadi, Adnan A.
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8125647/
https://ncbi.nlm.nih.gov/pubmed/34063139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26092717
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