Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach

BACKGROUND: Ensartinib (ESB) is a novel anaplastic lymphoma kinase inhibitor (ALK) with additional activity against Abelson murine leukemia (ABL), met proto-oncogene (MET), receptor tyrosine kinase (AXL), and v-ros UR2 sarcoma virus oncogene homolog 1 (ROS1) and is considered a safer alternative for...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: Abdelhameed, Ali S, Attwa, Mohamed W, Kadi, Adnan A
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2020
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7721118/
https://ncbi.nlm.nih.gov/pubmed/33299299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S274018
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