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Development and validation of an HPLC–MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study
PURPOSE: To develop and validate a bio-analytical HPLC–MS/MS method for the determination of conivaptan (CVA) an arginine-vasopressin receptor blocker in human plasma and in rat liver microsomes (RLMs). METHODS: Analytes were separated on a reversed phase C18 column (50 mm × 2.1 mm, 1.8 μm). The mob...
Gardado en:
| Publicado en: | Chem Cent J |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer International Publishing
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5930294/ https://ncbi.nlm.nih.gov/pubmed/29717376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-018-0414-5 |
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