A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L

The OAS/RNase L pathway is one of the best-characterized effector pathways of the IFN antiviral response. It inhibits the replication of many viruses and ultimately promotes apoptosis of infected cells, contributing to the control of virus spread. However, viruses have evolved a range of escape stra...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Pathog
Egile Nagusiak: Drappier, Melissa, Jha, Babal Kant, Stone, Sasha, Elliott, Ruth, Zhang, Rong, Vertommen, Didier, Weiss, Susan R., Silverman, Robert H., Michiels, Thomas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2018
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927464/
https://ncbi.nlm.nih.gov/pubmed/29652922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006989
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