Cisplatin‐incorporated Polymeric Micelles Eliminate Nephrotoxicity, While Maintaining Antitumor Activity

cis‐Diamminedichloroplatinum (II) (cisplatin, CDDP), a potent anticancer agent, was bound to the aspartic acid residues of poly(ethylene glycol)‐poly(aspartic acid) (PEG‐P(ASP)) block copolymer by ligand substitution reaction at the platinum atom of CDDP. The polymeric drug thus obtained was observe...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Mizumura, Yasuo, Matsumura, Yasuhiro, Hamaguchi, Tetsuya, Nishiyama, Nobuhiro, Kataoka, Kazunori, Kawaguchi, Takanori, Hrushesky, William J. M., Moriyasu, Fuminori, Kakizoe, Tadao
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926709/
https://ncbi.nlm.nih.gov/pubmed/11267944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2001.tb01099.x
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