Cisplatin‐incorporated Polymeric Micelles Eliminate Nephrotoxicity, While Maintaining Antitumor Activity

cis‐Diamminedichloroplatinum (II) (cisplatin, CDDP), a potent anticancer agent, was bound to the aspartic acid residues of poly(ethylene glycol)‐poly(aspartic acid) (PEG‐P(ASP)) block copolymer by ligand substitution reaction at the platinum atom of CDDP. The polymeric drug thus obtained was observe...

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Foilsithe in:Jpn J Cancer Res
Main Authors: Mizumura, Yasuo, Matsumura, Yasuhiro, Hamaguchi, Tetsuya, Nishiyama, Nobuhiro, Kataoka, Kazunori, Kawaguchi, Takanori, Hrushesky, William J. M., Moriyasu, Fuminori, Kakizoe, Tadao
Formáid: Artigo
Teanga:Inglês
Foilsithe: Blackwell Publishing Ltd 2001
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926709/
https://ncbi.nlm.nih.gov/pubmed/11267944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2001.tb01099.x
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