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An efficient platform for generating somatic point mutations with germline transmission in the zebrafish by CRISPR/Cas9-mediated gene editing
Homology-directed recombination (HDR)–mediated genome editing is a powerful approach for both basic functional study and disease modeling. Although some studies have reported HDR-mediated precise editing in nonrodent models, the efficiency of establishing pure mutant animal lines that carry specific...
Guardat en:
| Publicat a: | J Biol Chem |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5925810/ https://ncbi.nlm.nih.gov/pubmed/29500194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001080 |
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