Pharmacologically targeting the myristoylation of the scaffold protein FRS2α inhibits FGF/FGFR-mediated oncogenic signaling and tumor progression

Fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling facilitates tumor initiation and progression. Although currently approved inhibitors of FGFR kinase have shown therapeutic benefit in clinical trials, overexpression or mutations of FGFRs eventually confer drug resistance and thereby abrog...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Li, Qianjin, Alsaidan, Omar Awad, Ma, Yongjie, Kim, Sungjin, Liu, Junchen, Albers, Thomas, Liu, Kebin, Beharry, Zanna, Zhao, Shaying, Wang, Fen, Lebedyeva, Iryna, Cai, Houjian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2018
Aiheet:
Signal Transduction
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5925806/
https://ncbi.nlm.nih.gov/pubmed/29540482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000940
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