Blocking myristoylation of Src inhibits its kinase activity and suppresses prostate cancer progression

Protein N-myristoylation enables localization to membranes and helps maintain protein conformation and function. N-myristoyltransferases (NMT) catalyze co- or post-translational myristoylation of Src family kinases and other oncogenic proteins, thereby regulating their function. In this study, we pr...

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Publicado no:Cancer Res
Main Authors: Kim, Sungjin, Alsaidan, Omar Awad, Goodwin, Octavia, Li, Qianjin, Sulejmani, Essilvo, Han, Zhen, Bai, Aiping, Albers, Thomas, Beharry, Zanna, Zheng, Y. George, Norris, James S., Szulc, Zdzislaw M., Bielawska, Alicja, Lebedyeva, Iryna, Pegan, Scott D., Cai, Houjian
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732839/
https://ncbi.nlm.nih.gov/pubmed/29038344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0981
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