Pharmacologically targeting the myristoylation of the scaffold protein FRS2α inhibits FGF/FGFR-mediated oncogenic signaling and tumor progression

Fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling facilitates tumor initiation and progression. Although currently approved inhibitors of FGFR kinase have shown therapeutic benefit in clinical trials, overexpression or mutations of FGFRs eventually confer drug resistance and thereby abrog...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Li, Qianjin, Alsaidan, Omar Awad, Ma, Yongjie, Kim, Sungjin, Liu, Junchen, Albers, Thomas, Liu, Kebin, Beharry, Zanna, Zhao, Shaying, Wang, Fen, Lebedyeva, Iryna, Cai, Houjian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5925806/
https://ncbi.nlm.nih.gov/pubmed/29540482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000940
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