Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

BACKGROUND: Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and suppression of obesity and diabetes. However, the identity of the predominant metabolic tissue in which a major FGFR-KLB resides that critically m...

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Bibliographic Details
Main Authors: Yang, Chaofeng, Jin, Chengliu, Li, Xiaokun, Wang, Fen, McKeehan, Wallace L., Luo, Yongde
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307775/
https://ncbi.nlm.nih.gov/pubmed/22442730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033870
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