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Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

BACKGROUND: Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and suppression of obesity and diabetes. However, the identity of the predominant metabolic tissue in which a major FGFR-KLB resides that critically m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yang, Chaofeng, Jin, Chengliu, Li, Xiaokun, Wang, Fen, McKeehan, Wallace L., Luo, Yongde
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307775/
https://ncbi.nlm.nih.gov/pubmed/22442730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033870
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