Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity

OBJECTIVE: To signal, FGF19 and FGF21 require co-receptor βKlotho (KLB) to act in concert with FGF receptors, and yet there is appreciable variance in the C-terminal sequences of these two novel metabolic hormones where binding is believed to be primary. We seek to determine the functional consequen...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Agrawal, Archita, Parlee, Sebastian, Perez-Tilve, Diego, Li, Pengyun, Pan, Jia, Mroz, Piotr A., Kruse Hansen, Ann Maria, Andersen, Birgitte, Finan, Brian, Kharitonenkov, Alexei, DiMarchi, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026317/
https://ncbi.nlm.nih.gov/pubmed/29789271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.05.003
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