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Pervasive contingency and entrenchment in a billion years of Hsp90 evolution
Interactions among mutations within a protein have the potential to make molecular evolution contingent and irreversible, but the extent to which epistasis actually shaped historical evolutionary trajectories is unclear. To address this question, we experimentally measured how the fitness effects of...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5924896/ https://ncbi.nlm.nih.gov/pubmed/29626131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718133115 |
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