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Systematic mutant analyses elucidate general and client-specific aspects of Hsp90 function
To probe the mechanism of the Hsp90 chaperone that is required for the maturation of many signaling proteins in eukaryotes, we analyzed the effects of all individual amino acid changes in the ATPase domain on yeast growth rate. The sensitivity of a position to mutation was strongly influenced by pro...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4838542/ https://ncbi.nlm.nih.gov/pubmed/27068472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.03.046 |
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