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Latent Effects of Hsp90 Mutants Revealed at Reduced Expression Levels

In natural systems, selection acts on both protein sequence and expression level, but it is unclear how selection integrates over these two dimensions. We recently developed the EMPIRIC approach to systematically determine the fitness effects of all possible point mutants for important regions of es...

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Autors principals: Jiang, Li, Mishra, Parul, Hietpas, Ryan T., Zeldovich, Konstantin B., Bolon, Daniel N. A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694843/
https://ncbi.nlm.nih.gov/pubmed/23825969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003600
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