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Designed Hsp90 heterodimers reveal asymmetric ATPase-driven mechanism in vivo
Hsp90 is a homo-dimeric ATPase that is essential in eukaryotes for the maturation of client proteins frequently involved in signal transduction including many kinases and nuclear steroid hormone receptors. Competitive inhibitors of ATP binding to Hsp90 prevent client maturation and show promise as a...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3923517/ https://ncbi.nlm.nih.gov/pubmed/24462207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.12.024 |
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