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Mechanistic asymmetry in Hsp90 dimers

Hsp90 is a molecular chaperone that facilitates the maturation of signaling proteins including many kinases and steroid hormone receptors. Through these client proteins, Hsp90 is a key mediator of many physiological processes and has emerged as a promising drug target in cancer. Additionally, Hsp90...

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Foilsithe in:J Mol Biol
Main Authors: Flynn, Julia M., Mishra, Parul, Bolon, Daniel N. A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569507/
https://ncbi.nlm.nih.gov/pubmed/25843003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.03.017
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