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Pervasive contingency and entrenchment in a billion years of Hsp90 evolution
Interactions among mutations within a protein have the potential to make molecular evolution contingent and irreversible, but the extent to which epistasis actually shaped historical evolutionary trajectories is unclear. To address this question, we experimentally measured how the fitness effects of...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5924896/ https://ncbi.nlm.nih.gov/pubmed/29626131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718133115 |
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