GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation

The growth hormone secretagogue receptor (GHSR) and dopamine receptor (D2R) have been shown to oligomerize in hypothalamic neurons with a significant effect on dopamine signaling, but the molecular processes underlying this effect are still obscure. We used here the purified GHSR and D2R to establis...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Damian, Marjorie, Pons, Véronique, Renault, Pedro, M’Kadmi, Céline, Delort, Bartholomé, Hartmann, Lucie, Kaya, Ali I., Louet, Maxime, Gagne, Didier, Ben Haj Salah, Khoubaib, Denoyelle, Séverine, Ferry, Gilles, Boutin, Jean A., Wagner, Renaud, Fehrentz, Jean-Alain, Martinez, Jean, Marie, Jacky, Floquet, Nicolas, Galès, Céline, Mary, Sophie, Hamm, Heidi E., Banères, Jean-Louis
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924877/
https://ncbi.nlm.nih.gov/pubmed/29632174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712725115
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