Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network

RATIONALE: The Regulator of Calcineurin 1 (RCAN1) inhibits calcineurin (CN), a Ca(2+)-activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 in proximity to the “Down syndrome critical region.” The hearts and brains of Rcan1 KO mice are more susce...

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Publicado en:Circ Res
Main Authors: Parra, Valentina, Altamirano, Francisco, Hernández-Fuentes, Carolina P., Tong, Dan, Kyrychenko, Victoriia, Rotter, David, Pedrozo, Zully, Hill, Joseph A., Eisner, Verónica, Lavandero, Sergio, Schneider, Jay W., Rothermel, Beverly A.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924463/
https://ncbi.nlm.nih.gov/pubmed/29362227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.311522
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