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Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion

Many important components of the cardiovascular system display circadian rhythmicity. In both humans and mice, cardiac damage from ischemia/reperfusion (I/R) is greatest at the transition from sleep to activity. The causes of this window of susceptibility are not fully understood. In the murine hear...

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Hlavní autoři: Rotter, David, Grinsfelder, D. Bennett, Parra, Valentina, Pedrozo, Zully, Singh, Sarvjeet, Sachan, Nita, Rothermel, Beverly A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4114994/
https://ncbi.nlm.nih.gov/pubmed/24838101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.05.004
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