Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network

RATIONALE: The Regulator of Calcineurin 1 (RCAN1) inhibits calcineurin (CN), a Ca(2+)-activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 in proximity to the “Down syndrome critical region.” The hearts and brains of Rcan1 KO mice are more susce...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Parra, Valentina, Altamirano, Francisco, Hernández-Fuentes, Carolina P., Tong, Dan, Kyrychenko, Victoriia, Rotter, David, Pedrozo, Zully, Hill, Joseph A., Eisner, Verónica, Lavandero, Sergio, Schneider, Jay W., Rothermel, Beverly A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924463/
https://ncbi.nlm.nih.gov/pubmed/29362227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.311522
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