In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection

The antifungal effects of the novel triazole PC1244, designed for topical or inhaled administration, against Aspergillus fumigatus were tested in a range of in vitro and in vivo studies. PC1244 demonstrated potent antifungal activities against clinical A. fumigatus isolates (n = 96) with a MIC range...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Colley, Thomas, Sehra, Gurpreet, Chowdhary, Anuradha, Alanio, Alexandre, Kelly, Steven L., Kizawa, Yasuo, Armstrong-James, Darius, Fisher, Matthew C., Warrilow, Andrew G. S., Parker, Josie E., Kelly, Diane E., Kimura, Genki, Nishimoto, Yuki, Sunose, Mihiro, Onions, Stuart, Crepin, Damien, Lagasse, Franz, Crittall, Matthew, Shannon, Jonathan, McConville, Matthew, King-Underwood, John, Naylor, Alan, Bretagne, Stéphane, Murray, John, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923123/
https://ncbi.nlm.nih.gov/pubmed/29439966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01941-17
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