In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection

The antifungal effects of the novel triazole PC1244, designed for topical or inhaled administration, against Aspergillus fumigatus were tested in a range of in vitro and in vivo studies. PC1244 demonstrated potent antifungal activities against clinical A. fumigatus isolates (n = 96) with a MIC range...

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Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Colley, Thomas, Sehra, Gurpreet, Chowdhary, Anuradha, Alanio, Alexandre, Kelly, Steven L., Kizawa, Yasuo, Armstrong-James, Darius, Fisher, Matthew C., Warrilow, Andrew G. S., Parker, Josie E., Kelly, Diane E., Kimura, Genki, Nishimoto, Yuki, Sunose, Mihiro, Onions, Stuart, Crepin, Damien, Lagasse, Franz, Crittall, Matthew, Shannon, Jonathan, McConville, Matthew, King-Underwood, John, Naylor, Alan, Bretagne, Stéphane, Murray, John, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923123/
https://ncbi.nlm.nih.gov/pubmed/29439966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01941-17
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