D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model

Heterozygous mutations in glucocerebrosidase 1 (GBA1) are a major genetic risk factor for Parkinson’s disease and Dementia with Lewy bodies. Mutations in GBA1 leads to GBA1 enzyme deficiency, and GBA1-associated parkinsonism has an earlier age of onset and more progressive parkinsonism. To investiga...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Kim, Donghoon, Hwang, Heehong, Choi, Seulah, Kwon, Sang Ho, Lee, Suhyun, Park, Jae Hong, Kim, SangMin, Ko, Han Seok
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923019/
https://ncbi.nlm.nih.gov/pubmed/29703245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0538-9
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