Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease

Glucocerebrosidase 1 (GBA) mutations responsible for Gaucher disease (GD) are the most common genetic risk factor for Parkinson's disease (PD). Although the genetic link between GD and PD is well established, the underlying molecular mechanism(s) are not well understood. We propose that glucosy...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Taguchi, Yumiko V., Liu, Jun, Ruan, Jiapeng, Pacheco, Joshua, Zhang, Xiaokui, Abbasi, Justin, Keutzer, Joan, Mistry, Pramod K., Chandra, Sreeganga S.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628407/
https://ncbi.nlm.nih.gov/pubmed/28847804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1525-17.2017
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