Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system

DNA damage tolerance (DDT) enables replication to continue in the presence of a damaged template and constitutes a key step in DNA interstrand crosslink repair. In this way DDT minimizes replication stress inflicted by a wide range of endogenous and exogenous agents, and provides a critical first li...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Aslam, Muhammad Assad, Zavrakidis, Ioannis, van der Wiel, Rianne, van de Ven, Marieke, van den Berk, Paul C.M., Jacobs, Heinz
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922359/
https://ncbi.nlm.nih.gov/pubmed/29721165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24777
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