The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity

The antihelmintic drug ABZ and its metabolites belong to the chemical family of benzimidazoles (BZM) that act as potent tubulin polymerization inhibitors, suggesting a potential re-direction of BZMs for cancer therapy. Applying UV-Vis spectrometry we here demonstrate ABZ as a DNA intercalator. This...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Will Castro, Luiza S. E. P., Pieters, Wietske, Alemdehy, Mir Farshid, Aslam, Muhammad A., Buoninfante, Olimpia Alessandra, Raaijmakers, Jonne A., Pilzecker, Bas, van den Berk, Paul C. M., te Riele, Hein, Medema, René H., Pedrosa, Rozangela C., Jacobs, Heinz
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935534/
https://ncbi.nlm.nih.gov/pubmed/33679394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.596535
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