Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm

Loss-of-function mutations in genes encoding contractile proteins have been observed in thoracic aortic aneurysms (TAA). To gain insight into the contribution of contractile protein deficiency in the pathogenesis of TAA, we examined human aneurysm samples. We found multiple contractile gene products...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Lino Cardenas, Christian L., Kessinger, Chase W., MacDonald, Carolyn, Jassar, Arminder S., Isselbacher, Eric M., Jaffer, Farouc A., Lindsay, Mark E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922285/
https://ncbi.nlm.nih.gov/pubmed/29515022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97493
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