Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm

Loss-of-function mutations in genes encoding contractile proteins have been observed in thoracic aortic aneurysms (TAA). To gain insight into the contribution of contractile protein deficiency in the pathogenesis of TAA, we examined human aneurysm samples. We found multiple contractile gene products...

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Vydáno v:JCI Insight
Hlavní autoři: Lino Cardenas, Christian L., Kessinger, Chase W., MacDonald, Carolyn, Jassar, Arminder S., Isselbacher, Eric M., Jaffer, Farouc A., Lindsay, Mark E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922285/
https://ncbi.nlm.nih.gov/pubmed/29515022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97493
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