In vitro Enhancement of Antitumor Activity of a Water‐soluble Duocarmycin Derivative, KW‐2189, by Caffeine‐mediated DNA‐repair Inhibition in Human Lung Cancer Cells

Duocarmycins, including KW‐2189, bind in the minor groove of double‐stranded DNA at A‐T‐rich sequences, followed by covalent bonding with N‐3 of adenine in preferred sequences. We examined the effect of DNA‐repair modulators, such as caffeine and aphidicolin, on the cytotoxicity of duocarmycins towa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Jpn J Cancer Res
Prif Awduron: Ogasawara, Hayato, Nishio, Kazuto, Ishida, Tomoyuki, Arioka, Hitoshi, Fukuoka, Kazuya, Saijo, Nagahiro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Publishing Ltd 1997
Pynciau:
Rapid Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921316/
https://ncbi.nlm.nih.gov/pubmed/9439677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00326.x
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