Effect of Glutathione Depletion on Cisplatin Resistance in Cancer Cells Transfected with the γ‐Glutamylcysteine Synthetase Gene

Overexpression of the human γ‐glutamylcysteine synthetase (γ‐GCS) gene resulted in cisplatin resistance with an increased glutathione (GSH) content, increased ATP‐dependent glutatbione S‐conjugate export pump (GS‐X pump) activity and decreased platinum accumulation in human lung cancer cells transfe...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Kurokawa, Hirokazu, Nishio, Kazuto, Ishida, Tomoyuki, Arioka, Hitoshi, Fukuoka, Kazuya, Nomoto, Taisuke, Fukumoto, Hisao, Yokote, Hideyuki, Saijo, Nagahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1997
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921367/
https://ncbi.nlm.nih.gov/pubmed/9119737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00354.x
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