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Effect of Glutathione Depletion on Cisplatin Resistance in Cancer Cells Transfected with the γ‐Glutamylcysteine Synthetase Gene

Overexpression of the human γ‐glutamylcysteine synthetase (γ‐GCS) gene resulted in cisplatin resistance with an increased glutathione (GSH) content, increased ATP‐dependent glutatbione S‐conjugate export pump (GS‐X pump) activity and decreased platinum accumulation in human lung cancer cells transfe...

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Bibliografische gegevens
Gepubliceerd in:Jpn J Cancer Res
Hoofdauteurs: Kurokawa, Hirokazu, Nishio, Kazuto, Ishida, Tomoyuki, Arioka, Hitoshi, Fukuoka, Kazuya, Nomoto, Taisuke, Fukumoto, Hisao, Yokote, Hideyuki, Saijo, Nagahiro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Blackwell Publishing Ltd 1997
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921367/
https://ncbi.nlm.nih.gov/pubmed/9119737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00354.x
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